Endocrine Abstracts

Maternal hypothyroidism disrupts fetal brain development in the rat; affected parameters include several neuron-specific cytoskeletal proteins and neurotransmitter metabolic enzymes. The aim of this study was to determine whether maternal hyperthyroidism also impacts upon fetal neuronal development.Partially thyroidectomised rat dams were subcutaneously implanted with osmotic pumps to infuse either 1.5 micrograms thyroxine/100 g body weight/day (HYPER) o...